Version 5.4
Homo sapiens Gene: NFKBIB
Summary
InnateDB Gene IDBG-49787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIB
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Synonyms IKBB; TRIP9
Species Homo sapiens
Ensembl Gene ENSG00000104825
Encoded Proteins
IDBP-49789
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
IDBP-246392
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
IDBP-591108
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
IDBP-765086
IDBP-764814
IDBP-764628
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 9346485
Inhibitor of NF-kappaB, binds to both NF-kappaB subunit nuclear localization signals and NFkappaB
Entrez Gene
Summary The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38899700-38908893
Strand Forward strand
Band q13.2
Transcripts
ENST00000313582 ENSP00000312988
ENST00000392079 ENSP00000375929
ENST00000509705 ENSP00000438598
ENST00000575359 ENSP00000458685
ENST00000576510 ENSP00000461617
ENST00000572515 ENSP00000459728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 59 [view]
Protein-Protein 54 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0032481 positive regulation of type I interferon production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030595
View Gene Order
ENSBTAG00000001778
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_13
IL1 pathway
NetPath_23
TSH pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
hsa05140
Leishmaniasis pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
B cell receptor signaling pathway
INOH website
TNFR1 signaling pathway pathway
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL I3L4X3
UniProt Splice Variant
Entrez Gene 4793
UniGene Hs.9731
RefSeq NM_001243116 NM_002503 XM_006723227
HUGO HGNC:7798
OMIM 604495
CCDS CCDS12524 CCDS74362
HPRD 07260
IMGT
EMBL AC011455
GenPept
RNA Seq Atlas 4793

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca