InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRA1D

Summary

InnateDB Gene

IDBG-49790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA1D

Gene Name

adrenoceptor alpha 1D

Synonyms

ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2

Species

Homo sapiens

Ensembl Gene

ENSG00000171873

Encoded Proteins

IDBP-49792

adrenergic, alpha-1D-, receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:4220631-4249074

Strand

Reverse strand

Band

p13

Transcripts

ENST00000379453	ENSP00000368766
ENST00000621688

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity

Biological Process

GO:0001986	negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0006259	DNA metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027335

View Gene Order

ENSBTAG00000019504

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_18407

G alpha (12/13) signalling events pathway

REACT_16927

Adrenoceptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04970

Salivary secretion pathway

INOH

PID NCI

Cross-References

SwissProt

P25100

TrEMBL

B0ZBE0

UniProt Splice Variant

Entrez Gene

146

UniGene

Hs.557

RefSeq

NM_000678

HUGO

HGNC:280

OMIM

104219

CCDS

CCDS13079

HPRD

00079

IMGT

EMBL

AL121675 AL357040 CH471133 D29952 EU326302 L31772 M76446 S70782 U03864

GenPept

AAA35496 AAB31163 AAB59487 AAB60351 ACA05908 BAA06222 CAC00601 EAX10455

RNA Seq Atlas

146