Homo sapiens Gene: PCDHB12
Summary
InnateDB Gene IDBG-50135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHB12
Gene Name protocadherin beta 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120328
Encoded Proteins
protocadherin beta 12
protocadherin beta 12
protocadherin beta 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141208697-141212571
Strand Forward strand
Band q31.3
Transcripts
ENST00000239450 ENSP00000239450
ENST00000624949 ENSP00000485303
ENST00000622978 ENSP00000485352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007399 nervous system development
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9Y5F1
TrEMBL
UniProt Splice Variant
Entrez Gene 56124
UniGene Hs.735812
RefSeq NM_018932
HUGO HGNC:8683
OMIM 606338
CCDS CCDS4254
HPRD
IMGT
EMBL AC005752 AF152491 AF217746 AK293336 AK316160 BC045637
GenPept AAD43752 AAH45637 AAK51614 BAG56852 BAH14531
RNA Seq Atlas 56124