InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COL4A1

Summary

InnateDB Gene

IDBG-50258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL4A1

Gene Name

collagen, type IV, alpha 1

Synonyms

arresten; HANAC; ICH; POREN1

Species

Homo sapiens

Ensembl Gene

ENSG00000187498

Encoded Proteins

IDBP-50260

collagen, type IV, alpha 1

IDBP-585019

collagen, type IV, alpha 1

IDBP-806799

collagen, type IV, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:110148963-110307149

Strand

Reverse strand

Band

q34

Transcripts

ENST00000375820	ENSP00000364979
ENST00000467182
ENST00000474391
ENST00000543140	ENSP00000443348
ENST00000615732	ENSP00000478222

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0030023	extracellular matrix constituent conferring elasticity
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007528	neuromuscular junction development
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0030855	epithelial cell differentiation
GO:0048514	blood vessel morphogenesis
GO:0061304	retinal blood vessel morphogenesis
GO:0061333	renal tubule morphogenesis
GO:0071230	cellular response to amino acid stimulus
GO:0071711	basement membrane organization

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005587	collagen type IV trimer
GO:0005604	basement membrane
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix