Homo sapiens Gene: COL4A1
Summary
InnateDB Gene IDBG-50258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL4A1
Gene Name collagen, type IV, alpha 1
Synonyms arresten; HANAC; ICH; POREN1;
Species Homo sapiens
Ensembl Gene ENSG00000187498
Encoded Proteins
collagen, type IV, alpha 1
collagen, type IV, alpha 1
collagen, type IV, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:110148963-110307149
Strand Reverse strand
Band q34
Transcripts
ENST00000375820 ENSP00000364979
ENST00000467182
ENST00000474391
ENST00000543140 ENSP00000443348
ENST00000615732 ENSP00000478222
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0030023 extracellular matrix constituent conferring elasticity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007528 neuromuscular junction development
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0030855 epithelial cell differentiation
GO:0048514 blood vessel morphogenesis
GO:0061304 retinal blood vessel morphogenesis
GO:0061333 renal tubule morphogenesis
GO:0071230 cellular response to amino acid stimulus
GO:0071711 basement membrane organization
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005587 collagen type IV trimer
GO:0005604 basement membrane
GO:0005788 endoplasmic reticulum lumen
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
NCAM signaling for neurite out-growth pathway
Degradation of the extracellular matrix pathway
NCAM1 interactions pathway
Axon guidance pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Signal Transduction pathway
Scavenging by Class A Receptors pathway
Integrin cell surface interactions pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen degradation pathway
Signaling by PDGF pathway
Collagen formation pathway
Anchoring fibril formation pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Protein digestion and absorption pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Platelet amyloid precursor protein pathway [Biocarta view]
Regulators of bone mineralization [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.17441
RefSeq NM_001845
HUGO
OMIM
CCDS CCDS9511
HPRD 00359
IMGT
EMBL
GenPept
RNA Seq Atlas