Homo sapiens Gene: PCDHGA2
Summary
InnateDB Gene IDBG-50428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHGA2
Gene Name protocadherin gamma subfamily A, 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000081853
Encoded Proteins
protocadherin gamma subfamily A, 2
protocadherin gamma subfamily A, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141338760-141512979
Strand Forward strand
Band q31.3
Transcripts
ENST00000394576 ENSP00000378077
ENST00000528330 ENSP00000483020
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9Y5H1
TrEMBL Q9BT64 Q9UKW1
UniProt Splice Variant
Entrez Gene 56113
UniGene
RefSeq NM_018915 NM_032009
HUGO HGNC:8700
OMIM 606289
CCDS CCDS47289
HPRD 07552
IMGT
EMBL AF119570 AF152322 AF152508 BC004321 BC093871 BC104950 CH471062
GenPept AAD43716 AAD43769 AAF03087 AAH04321 AAH93871 AAI04951 EAW61941
RNA Seq Atlas 56113