Version 5.4
Homo sapiens Gene: SUPT5H
Summary
InnateDB Gene IDBG-50457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUPT5H
Gene Name suppressor of Ty 5 homolog (S. cerevisiae)
Synonyms SPT5; SPT5H; Tat-CT1
Species Homo sapiens
Ensembl Gene ENSG00000196235
Encoded Proteins
IDBP-50461
suppressor of Ty 5 homolog (S. cerevisiae)
IDBP-294940
suppressor of Ty 5 homolog (S. cerevisiae)
IDBP-379873
suppressor of Ty 5 homolog (S. cerevisiae)
IDBP-763196
IDBP-765967
IDBP-764555
IDBP-762939
IDBP-766030
IDBP-761680
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39436156-39476670
Strand Forward strand
Band q13.2
Transcripts
ENST00000359191 ENSP00000352117
ENST00000402194 ENSP00000384505
ENST00000432763 ENSP00000404029
ENST00000598459
ENST00000598520
ENST00000598786
ENST00000598117
ENST00000594729 ENSP00000470595
ENST00000599335
ENST00000601978
ENST00000600818
ENST00000594990 ENSP00000471561
ENST00000598725 ENSP00000469090
ENST00000599907
ENST00000593727 ENSP00000469915
ENST00000599117 ENSP00000470252
ENST00000596208
ENST00000595368
ENST00000601515 ENSP00000472675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 79 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006338 chromatin remodeling
GO:0006354 DNA-dependent transcription, elongation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0007049 cell cycle
GO:0010033 response to organic substance
GO:0010467 gene expression
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0032784 regulation of DNA-templated transcription, elongation
GO:0032785 negative regulation of DNA-dependent transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0032044 DSIF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003435
View Gene Order
ENSBTAG00000010467
Not yet available
Pathways
NETPATH
REACTOME
REACT_6344
Tat-mediated HIV elongation arrest and recovery pathway
REACT_6143
Pausing and recovery of Tat-mediated HIV elongation pathway
REACT_1470
mRNA Capping pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_975
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6244
Pausing and recovery of HIV elongation pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6237
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_6259
HIV elongation arrest and recovery pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O00267
TrEMBL B4DZJ7 B4E0Q4 M0R105 M0R2M5
UniProt Splice Variant
Entrez Gene 723805
UniGene Hs.631604
RefSeq NM_001111020 NM_001130824 NM_003169 XM_005259183 NM_001130825 XM_006723337
HUGO HGNC:11469
OMIM 602102
CCDS CCDS12536 CCDS46072
HPRD 03655
IMGT
EMBL AB000516 AB209257 AC011500 AF040253 AK302954 AK303480 BC024203 CH471126 U56402 Y12790
GenPept AAC51102 AAD02179 AAH24203 BAA24075 BAD92494 BAG64109 BAG64516 CAA73326 EAW56896 EAW56897 EAW56898 EAW56899
RNA Seq Atlas 6829 723805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca