Version 5.4
Homo sapiens Gene: CLC
Summary
InnateDB Gene IDBG-50749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLC
Gene Name Charcot-Leyden crystal protein
Synonyms Gal-10; GAL10; LGALS10; LGALS10A; LPPL_HUMAN
Species Homo sapiens
Ensembl Gene ENSG00000105205
Encoded Proteins
IDBP-50751
Charcot-Leyden crystal protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39731250-39738028
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221804 ENSP00000221804
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0007275 multicellular organismal development
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q05315
TrEMBL
UniProt Splice Variant
Entrez Gene 1178
UniGene
RefSeq NM_001828
HUGO HGNC:2014
OMIM 153310
CCDS CCDS33025
HPRD
IMGT
EMBL AC005393 AC006133 BC119711 BC119712 CH471126 FJ613334 FJ613335 L01664 L01665 U68393 U68395 U68396 U68398
GenPept AAA36190 AAC28912 AAC37530 AAC51157 AAI19712 AAI19713 ACR09636 ACR09637 EAW56914
RNA Seq Atlas 1178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca