Homo sapiens Gene: CER1
Summary
InnateDB Gene IDBG-50819.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CER1
Gene Name cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
Synonyms DAND4;
Species Homo sapiens
Ensembl Gene ENSG00000147869
Encoded Proteins
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:14719724-14722717
Strand Reverse strand
Band p22.3
Transcripts
ENST00000380911 ENSP00000370297
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0016015 morphogen activity
GO:0036122 BMP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001657 ureteric bud development
GO:0003419 growth plate cartilage chondrocyte proliferation
GO:0007369 gastrulation
GO:0007399 nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030282 bone mineralization
GO:0030509 BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0035582 sequestering of BMP in extracellular matrix
GO:0042074 cell migration involved in gastrulation
GO:0048263 determination of dorsal identity
GO:0071773 cellular response to BMP stimulus
GO:2000381 negative regulation of mesoderm development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Regulation of signaling by NODAL pathway
Signal Transduction pathway
Signaling by BMP pathway
Signaling by NODAL pathway
KEGG
Wnt signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
BMP receptor signaling
Cross-References
SwissProt O95813
TrEMBL
UniProt Splice Variant
Entrez Gene 9350
UniGene Hs.248204
RefSeq NM_005454
HUGO HGNC:1862
OMIM 603777
CCDS CCDS6476
HPRD
IMGT
EMBL AF090189 AF400435 AL390732 BC069371 BC069405 BC069491 BC069503
GenPept AAD19879 AAH69371 AAH69405 AAH69491 AAH69503 AAK92484 CAH73850
RNA Seq Atlas 9350