InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CER1

Summary

InnateDB Gene

IDBG-50819.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CER1

Gene Name

cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)

Synonyms

DAND4

Species

Homo sapiens

Ensembl Gene

ENSG00000147869

Encoded Proteins

IDBP-50821

cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:14719724-14722717

Strand

Reverse strand

Band

p22.3

Transcripts

ENST00000380911

ENSP00000370297

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0016015	morphogen activity
GO:0036122	BMP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001657	ureteric bud development
GO:0003419	growth plate cartilage chondrocyte proliferation
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0009948	anterior/posterior axis specification
GO:0009952	anterior/posterior pattern specification
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030282	bone mineralization
GO:0030509	BMP signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0035582	sequestering of BMP in extracellular matrix
GO:0042074	cell migration involved in gastrulation
GO:0048263	determination of dorsal identity
GO:0071773	cellular response to BMP stimulus
GO:2000381	negative regulation of mesoderm development

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038192

View Gene Order

ENSBTAG00000020140

Not yet available

Pathways

NETPATH

REACTOME

REACT_12034

Signaling by BMP pathway

REACT_111059

Regulation of signaling by NODAL pathway

REACT_111057

Signaling by NODAL pathway

REACT_111045

Developmental Biology pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04310

Wnt signaling pathway pathway

INOH

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

O95813

TrEMBL

UniProt Splice Variant

Entrez Gene

9350

UniGene

Hs.248204

RefSeq

NM_005454

HUGO

HGNC:1862

OMIM

603777

CCDS

CCDS6476

HPRD

IMGT

EMBL

AF090189 AF400435 AL390732 BC069371 BC069405 BC069491 BC069503

GenPept

AAD19879 AAH69371 AAH69405 AAH69491 AAH69503 AAK92484 CAH73850

RNA Seq Atlas

9350