Version 5.4
Homo sapiens Gene: TIGIT
Summary
InnateDB Gene IDBG-50851.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIGIT
Gene Name T cell immunoreceptor with Ig and ITIM domains
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000181847
Encoded Proteins
IDBP-50853
T cell immunoreceptor with Ig and ITIM domains
IDBP-481182
T cell immunoreceptor with Ig and ITIM domains
IDBP-478590
T cell immunoreceptor with Ig and ITIM domains
IDBP-484853
T cell immunoreceptor with Ig and ITIM domains
IDBP-477191
T cell immunoreceptor with Ig and ITIM domains
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:114276913-114310288
Strand Forward strand
Band q13.31
Transcripts
ENST00000383671 ENSP00000373167
ENST00000461158 ENSP00000418917
ENST00000481065 ENSP00000420552
ENST00000486257 ENSP00000419085
ENST00000485814
ENST00000484319 ENSP00000419706
ENST00000496848
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0032695 negative regulation of interleukin-12 production
GO:0032733 positive regulation of interleukin-10 production
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071552
View Gene Order
ENSBTAG00000011921
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.421750 Hs.619510
RefSeq NM_173799 XM_005247206
HUGO
OMIM
CCDS CCDS2980
HPRD 08804
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca