Version 5.4
Homo sapiens Gene: SPRY4
Summary
InnateDB Gene IDBG-51215.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRY4
Gene Name sprouty homolog 4 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187678
Encoded Proteins
IDBP-51217
sprouty homolog 4 (Drosophila)
IDBP-379179
sprouty homolog 4 (Drosophila)
IDBP-481700
sprouty homolog 4 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142310427-142326455
Strand Reverse strand
Band q31.3
Transcripts
ENST00000344120 ENSP00000344967
ENST00000434127 ENSP00000399468
ENST00000511815 ENSP00000424411
ENST00000503582
ENST00000509364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
GO:0043407 negative regulation of MAP kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024427
View Gene Order
ENSBTAG00000008250
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.323308 Hs.597309 Hs.618816
RefSeq NM_001127496 NM_001293289 NM_001293290 NM_030964 XM_005268518 XM_005268519 XM_006714798
HUGO
OMIM
CCDS CCDS4274 CCDS47296
HPRD 10466
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca