InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MTA2

Summary

InnateDB Gene

IDBG-51223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTA2

Gene Name

metastasis associated 1 family, member 2

Synonyms

MTA1L1; PID

Species

Homo sapiens

Ensembl Gene

ENSG00000149480

Encoded Proteins

IDBP-51225

metastasis associated 1 family, member 2

IDBP-602331

metastasis associated 1 family, member 2

IDBP-603631

metastasis associated 1 family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:62593214-62601840

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000278823	ENSP00000278823
ENST00000524902	ENSP00000431346
ENST00000527204	ENSP00000431797
ENST00000531179
ENST00000531261
ENST00000526844
ENST00000532239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 147 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	147 [view]
Protein-Protein	145 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000989	transcription factor binding transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031492	nucleosomal DNA binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006333	chromatin assembly or disassembly
GO:0006355	regulation of transcription, DNA-templated
GO:0016575	histone deacetylation
GO:0043044	ATP-dependent chromatin remodeling
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0016020	membrane
GO:0016581	NuRD complex
GO:0043234	protein complex