Version 5.4
Homo sapiens Gene: VIPR2
Summary
InnateDB Gene IDBG-51262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VIPR2
Gene Name vasoactive intestinal peptide receptor 2
Synonyms C16DUPq36.3; DUP7q36.3; PACAP-R-3; PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R
Species Homo sapiens
Ensembl Gene ENSG00000106018
Encoded Proteins
IDBP-51264
vasoactive intestinal peptide receptor 2
IDBP-51266
vasoactive intestinal peptide receptor 2
IDBP-293607
vasoactive intestinal peptide receptor 2
IDBP-387687
vasoactive intestinal peptide receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:159028175-159144957
Strand Reverse strand
Band q36.3
Transcripts
ENST00000262178 ENSP00000262178
ENST00000377633 ENSP00000366860
ENST00000402066 ENSP00000384497
ENST00000421760 ENSP00000402690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007267 cell-cell signaling
GO:0048662 negative regulation of smooth muscle cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000011171
View Gene Order
ENSBTAG00000037649
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P41587
TrEMBL Q71V81 X5D7Q6
UniProt Splice Variant
Entrez Gene 7434
UniGene Hs.585052
RefSeq NM_003382 XM_005249561
HUGO HGNC:12695
OMIM 601970
CCDS CCDS5950
HPRD 03576
IMGT
EMBL AF027390 BC010569 BT007118 CH236954 CH471149 KJ534960 L36566 L40764 U18810 X95097 Y18423 Y18424 Y18425 Y18426 Y18427 Y18428 Y18429 Y18430 Y18431
GenPept AAC09171 AAC37569 AAC41756 AAC50872 AAH10569 AAP35782 AHW56600 CAA64474 CAB41899 EAL23936 EAX04596
RNA Seq Atlas 7434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca