Homo sapiens Gene: PRKCQ
Summary
InnateDB Gene IDBG-51302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKCQ
Gene Name protein kinase C, theta
Synonyms nPKC-theta; PRKCT;
Species Homo sapiens
Ensembl Gene ENSG00000065675
Encoded Proteins
protein kinase C, theta
protein kinase C, theta
protein kinase C, theta
protein kinase C, theta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:6427143-6580301
Strand Reverse strand
Band p15.1
Transcripts
ENST00000263125 ENSP00000263125
ENST00000397176 ENSP00000380361
ENST00000539722 ENSP00000441752
ENST00000610727 ENSP00000483428
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006509 membrane protein ectodomain proteolysis
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0006954 inflammatory response
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0007603 phototransduction, visible light
GO:0016056 rhodopsin mediated signaling pathway
GO:0016567 protein ubiquitination
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030168 platelet activation
GO:0032740 positive regulation of interleukin-17 production
GO:0032753 positive regulation of interleukin-4 production
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070233 negative regulation of T cell apoptotic process
GO:0090330 regulation of platelet aggregation
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000570 positive regulation of T-helper 2 cell activation
Cellular Component
GO:0001772 immunological synapse
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
TNFalpha pathway
TCR pathway
BCR pathway
REACTOME
Apoptotic execution phase pathway
Developmental Biology pathway
FCERI mediated NF-kB activation pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
TCR signaling pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Netrin-1 signaling pathway
Adaptive Immune System pathway
Apoptotic cleavage of cellular proteins pathway
Diseases associated with visual transduction pathway
Immune System pathway
G alpha (z) signalling events pathway
Effects of PIP2 hydrolysis pathway
Downstream TCR signaling pathway
Visual phototransduction pathway
The phototransduction cascade pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
Disease pathway
Hemostasis pathway
KEGG
Vascular smooth muscle contraction pathway
Tight junction pathway
T cell receptor signaling pathway pathway
Adipocytokine signaling pathway pathway
INOH
GPCR signaling pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
Keratinocyte differentiation [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
TCR signaling in na´ve CD4+ T cells
Downstream signaling in na´ve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt Q04759
TrEMBL
UniProt Splice Variant
Entrez Gene 5588
UniGene Hs.498570 Hs.619393
RefSeq NM_001282644 NM_006257 XM_005252496 XM_006717465 NM_001242413 NM_001282645
HUGO HGNC:9410
OMIM 600448
CCDS CCDS7079 CCDS55701 CCDS60482
HPRD 02710
IMGT
EMBL AK293935 AL137145 AL158043 AY702977 BC101465 BC113359 L01087 L07032
GenPept AAA60101 AAA75571 AAI01466 AAI13360 AAU29340 BAG57313 CAC10200 CAC12904
RNA Seq Atlas 5588