InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKCQ

Summary

InnateDB Gene

IDBG-51302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCQ

Gene Name

protein kinase C, theta

Synonyms

nPKC-theta; PRKCT

Species

Homo sapiens

Ensembl Gene

ENSG00000065675

Encoded Proteins

IDBP-51304

protein kinase C, theta

IDBP-235926

protein kinase C, theta

IDBP-592589

protein kinase C, theta

IDBP-809571

protein kinase C, theta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:6427143-6580301

Strand

Reverse strand

Band

p15.1

Transcripts

ENST00000263125	ENSP00000263125
ENST00000397176	ENSP00000380361
ENST00000539722	ENSP00000441752
ENST00000610727	ENSP00000483428

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006509	membrane protein ectodomain proteolysis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006954	inflammatory response
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0016567	protein ubiquitination
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0030168	platelet activation
GO:0032740	positive regulation of interleukin-17 production
GO:0032753	positive regulation of interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070233	negative regulation of T cell apoptotic process
GO:0090330	regulation of platelet aggregation
GO:2000318	positive regulation of T-helper 17 type immune response
GO:2000570	positive regulation of T-helper 2 cell activation