Homo sapiens Gene: ROM1
Summary
InnateDB Gene IDBG-51305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROM1
Gene Name retinal outer segment membrane protein 1
Synonyms ROM; ROSP1; RP7; TSPAN23;
Species Homo sapiens
Ensembl Gene ENSG00000149489
Encoded Proteins
retinal outer segment membrane protein 1
retinal outer segment membrane protein 1
retinal outer segment membrane protein 1
retinal outer segment membrane protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62611722-62615120
Strand Forward strand
Band q12.3
Transcripts
ENST00000278833 ENSP00000278833
ENST00000525801 ENSP00000433566
ENST00000534093 ENSP00000432151
ENST00000529273
ENST00000525947 ENSP00000432983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0007601 visual perception
GO:0010468 regulation of gene expression
GO:0060042 retina morphogenesis in camera-type eye
GO:0060219 camera-type eye photoreceptor cell differentiation
GO:0061298 retina vasculature development in camera-type eye
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0042622 photoreceptor outer segment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL E9PKF5
UniProt Splice Variant
Entrez Gene 6094
UniGene Hs.281564
RefSeq NM_000327
HUGO HGNC:10254
OMIM 180721
CCDS CCDS8024
HPRD 01616
IMGT
EMBL AP001458
GenPept
RNA Seq Atlas 6094