Homo sapiens Gene: ASB3
Summary
InnateDB Gene IDBG-51647.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB3
Gene Name ankyrin repeat and SOCS box containing 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115239
Encoded Proteins
ankyrin repeat and SOCS box containing 3
ankyrin repeat and SOCS box containing 3
ankyrin repeat and SOCS box containing 3
ankyrin repeat and SOCS box containing 3
ankyrin repeat and SOCS box containing 3
ankyrin repeat and SOCS box containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. The transcript includes exons from both GPR75 and ASB3 and translation initiates in the 5' non-coding exon of GPR75. The resulting protein has a novel N-terminus but is otherwise identical to that encoded by ASB3.[provided by RefSeq, Feb 2011] The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:53532672-53787610
Strand Reverse strand
Band p16.2
Transcripts
ENST00000263634 ENSP00000263634
ENST00000352846 ENSP00000313756
ENST00000394717 ENSP00000378206
ENST00000406053 ENSP00000385137
ENST00000406625 ENSP00000385085
ENST00000406687 ENSP00000384728
ENST00000414369
ENST00000482339
ENST00000490794
ENST00000482829
ENST00000470707
ENST00000498475
ENST00000470916
ENST00000480522
ENST00000489508
ENST00000482134
ENST00000459916
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.40763
RefSeq NM_001201965 NM_016115 NM_145863 NM_001164165
HUGO
OMIM
CCDS CCDS1846 CCDS1847 CCDS54361
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas