Version 5.4
Homo sapiens Gene: HMHB1
Summary
InnateDB Gene IDBG-51761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMHB1
Gene Name histocompatibility (minor) HB-1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158497
Encoded Proteins
IDBP-51763
histocompatibility (minor) HB-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the minor histocompatibility antigens, which play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human histocompatibility leukocyte antigen (HLA)-identical allogeneic bone marrow transplantation (BMT). This gene is only expressed in B cell acute lymphoblastic leukemia cells and Epstein-Barr virus-transformed B cells. The translation of this mRNA initiates at a non-AUG (CUG) codon. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:143812161-143820719
Strand Forward strand
Band q31.3
Transcripts
ENST00000289448 ENSP00000289448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002376 immune system process
Cellular Component
Orthologs
No orthologs found for this gene
Cross-References
SwissProt O97980
TrEMBL
UniProt Splice Variant
Entrez Gene 57824
UniGene Hs.158320
RefSeq NM_021182
HUGO HGNC:29677
OMIM 609961
CCDS CCDS43376
HPRD
IMGT
EMBL AF103884 AF233094 BC104412 BC104413
GenPept AAC78642 AAF81110 AAI04413 AAI04414
RNA Seq Atlas 57824

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca