Version 5.4
Homo sapiens Gene: NXF1
Summary
InnateDB Gene IDBG-51882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NXF1
Gene Name nuclear RNA export factor 1
Synonyms MEX67; TAP
Species Homo sapiens
Ensembl Gene ENSG00000162231
Encoded Proteins
IDBP-51884
nuclear RNA export factor 1
IDBP-584372
nuclear RNA export factor 1
IDBP-601740
nuclear RNA export factor 1
IDBP-598662
nuclear RNA export factor 1
IDBP-590974
nuclear RNA export factor 1
IDBP-808633
nuclear RNA export factor 1
IDBP-601426
nuclear RNA export factor 1
IDBP-603605
nuclear RNA export factor 1
IDBP-601295
nuclear RNA export factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62792123-62806302
Strand Reverse strand
Band q12.3
Transcripts
ENST00000294172 ENSP00000294172
ENST00000531709 ENSP00000453885
ENST00000532297 ENSP00000436679
ENST00000527902 ENSP00000434301
ENST00000533048
ENST00000533499
ENST00000527497
ENST00000530875 ENSP00000435742
ENST00000533440
ENST00000531872
ENST00000531579
ENST00000526163
ENST00000531131 ENSP00000477375
ENST00000533671 ENSP00000431381
ENST00000525576 ENSP00000432530
ENST00000531474 ENSP00000437296
ENST00000527064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 129 [view]
Protein-Protein 120 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 9 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005487 nucleocytoplasmic transporter activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006810 transport
GO:0010467 gene expression
GO:0016032 viral process
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0051028 mRNA transport
Cellular Component
GO:0000346 transcription export complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0042405 nuclear inclusion body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010097
View Gene Order
ENSBTAG00000009488
Not yet available
Pathways
NETPATH
REACTOME
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_424
Transport of the SLBP independent Mature mRNA pathway
REACT_405
Transport of the SLBP Dependant Mature mRNA pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523739 Hs.623481
RefSeq NM_001081491 NM_006362 XM_006718418
HUGO
OMIM
CCDS CCDS44629 CCDS8037
HPRD 04035
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca