Version 5.4
Homo sapiens Gene: LTA4H
Summary
InnateDB Gene IDBG-51977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTA4H
Gene Name leukotriene A4 hydrolase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111144
Encoded Proteins
IDBP-51979
leukotriene A4 hydrolase
IDBP-381369
leukotriene A4 hydrolase
IDBP-583653
leukotriene A4 hydrolase
IDBP-586973
leukotriene A4 hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:96000828-96043520
Strand Reverse strand
Band q23.1
Transcripts
ENST00000228740 ENSP00000228740
ENST00000413268 ENSP00000395051
ENST00000537111
ENST00000552789 ENSP00000449958
ENST00000553041
ENST00000548852 ENSP00000449340
ENST00000547393
ENST00000548375
ENST00000547982
ENST00000552091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 11 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0004301 epoxide hydrolase activity
GO:0004463 leukotriene-A4 hydrolase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006508 proteolysis
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0043171 peptide catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015889
View Gene Order
ENSBTAG00000016415
Not yet available
Pathways
NETPATH
REACTOME
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt P09960
TrEMBL B4DEH5 Q49AK0
UniProt Splice Variant
Entrez Gene 4048
UniGene Hs.524648
RefSeq NM_000895 NM_001256643 NM_001256644
HUGO HGNC:6710
OMIM 151570
CCDS CCDS58266 CCDS58267 CCDS9059
HPRD
IMGT
EMBL AC007298 AK293630 AK298017 BC032528 BC036555 BX647158 CH471054 CR457068 J02959 J03459 U27275 U27276 U27277 U27278 U27279 U27280 U27281 U27282 U27283 U27284 U27285 U27286 U27287 U27288 U27289 U27290 U27291 U27292 U27293 U43410 U43411
GenPept AAA36176 AAA36177 AAA89077 AAH32528 AAH36555 BAG57086 BAG60321 CAG33349 EAW97559
RNA Seq Atlas 101928830 4048

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca