Homo sapiens Gene: ATP5C1
Summary
InnateDB Gene IDBG-52089.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5C1
Gene Name ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Synonyms ATP5C; ATP5CL1;
Species Homo sapiens
Ensembl Gene ENSG00000165629
Encoded Proteins
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:7788129-7807815
Strand Forward strand
Band p14
Transcripts
ENST00000356708 ENSP00000349142
ENST00000335698 ENSP00000338568
ENST00000493053
ENST00000462760
ENST00000460362
ENST00000465936
ENST00000460820
ENST00000472202
ENST00000473809
ENST00000480528
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 57 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016887 ATPase activity
GO:0022857 transmembrane transporter activity
GO:0044822 poly(A) RNA binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006119 oxidative phosphorylation
GO:0006200 ATP catabolic process
GO:0006754 ATP biosynthetic process
GO:0015986 ATP synthesis coupled proton transport
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Formation of ATP by chemiosmotic coupling pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P36542
TrEMBL B4DFE6 B4DL14
UniProt Splice Variant
Entrez Gene 509
UniGene
RefSeq NM_005174 NM_001001973
HUGO HGNC:833
OMIM 108729
CCDS CCDS7081 CCDS31142
HPRD 00156
IMGT
EMBL AK292896 AK294061 AK296803 AL158044 AL353754 BC000470 BC000931 BC013394 BC016812 BC020824 CH471072 CR457403 D16561 D16562 D16563
GenPept AAH00470 AAH00931 AAH13394 AAH16812 AAH20824 BAA03994 BAA03995 BAA03996 BAA03997 BAF85585 BAG57407 BAG59376 CAG33684 CAH73453 CAH73454 CAI12960 CAI12961 EAW86372 EAW86373
RNA Seq Atlas 509