Homo sapiens Gene: RND2
Summary
InnateDB Gene IDBG-52155.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RND2
Gene Name Rho family GTPase 2
Synonyms ARHN; RHO7; RhoN;
Species Homo sapiens
Ensembl Gene ENSG00000108830
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:43025241-43032036
Strand Forward strand
Band q21.31
Transcripts
ENST00000587250 ENSP00000466680
ENST00000587117
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0048672 positive regulation of collateral sprouting
Cellular Component
GO:0002080 acrosomal membrane
GO:0005622 intracellular
GO:0005769 early endosome
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Plexin-D1 Signaling
Cross-References
SwissProt P52198
TrEMBL F5H2U5
UniProt Splice Variant
Entrez Gene 8153
UniGene Hs.603111
RefSeq NM_005440 XM_005257706
HUGO HGNC:18315
OMIM 601555
CCDS CCDS11452
HPRD 03332
IMGT
EMBL AC135721 AF498968 AK290199 BC094842 BC104986 BC104990 BT019394 CH471152 L78833 X95456
GenPept AAC37595 AAH94842 AAI04987 AAI04991 AAM21115 AAV38201 BAF82888 CAA64726 EAW60920
RNA Seq Atlas 8153