Version 5.4
Homo sapiens Gene: CHRM1
Summary
InnateDB Gene IDBG-52216.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRM1
Gene Name cholinergic receptor, muscarinic 1
Synonyms HM1; M1; M1R
Species Homo sapiens
Ensembl Gene ENSG00000168539
Encoded Proteins
IDBP-52218
cholinergic receptor, muscarinic 1
IDBP-585741
cholinergic receptor, muscarinic 1
IDBP-598561
cholinergic receptor, muscarinic 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62908679-62921807
Strand Reverse strand
Band q12.3
Transcripts
ENST00000306960 ENSP00000306490
ENST00000543973 ENSP00000441188
ENST00000536524 ENSP00000444482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004930 G-protein coupled receptor activity
GO:0008144 drug binding
GO:0016907 G-protein coupled acetylcholine receptor activity
Biological Process
GO:0006464 cellular protein modification process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007274 neuromuscular synaptic transmission
GO:0007399 nervous system development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0040012 regulation of locomotion
GO:0043270 positive regulation of ion transport
GO:0046541 saliva secretion
GO:0050890 cognition
GO:0090316 positive regulation of intracellular protein transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032279 asymmetric synapse
GO:0043679 axon terminus
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032773
View Gene Order
ENSBTAG00000011579
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_16943
Muscarinic acetylcholine receptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632119
RefSeq NM_000738
HUGO
OMIM
CCDS CCDS8040
HPRD 00338
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca