Version 5.4
Homo sapiens Gene: EIF2S3
Summary
InnateDB Gene IDBG-52677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2S3
Gene Name eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
Synonyms eIF-2gA; EIF2; EIF2G; EIF2gamma
Species Homo sapiens
Ensembl Gene ENSG00000130741
Encoded Proteins
IDBP-52679
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
IDBP-365667
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:24054716-24077971
Strand Forward strand
Band p22.11
Transcripts
ENST00000253039 ENSP00000253039
ENST00000423068 ENSP00000391383
ENST00000487075
ENST00000460032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 30 [view]
Protein-DNA 5 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, nucleic acid binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006412 translation
GO:0006413 translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035150
View Gene Order
ENSBTAG00000014337
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_1815
Recycling of eIF2:GDP pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.539684 Hs.604373 Hs.662662
RefSeq NM_001415
HUGO
OMIM
CCDS CCDS14210
HPRD 02155
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca