Homo sapiens Gene: MBP
Summary
InnateDB Gene IDBG-5288.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBP
Gene Name myelin basic protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197971
Encoded Proteins
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
myelin basic protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:76978827-77133683
Strand Reverse strand
Band q23
Transcripts
ENST00000355994 ENSP00000348273
ENST00000354542 ENSP00000346545
ENST00000382582 ENSP00000372025
ENST00000359645 ENSP00000352667
ENST00000397875 ENSP00000380973
ENST00000397869 ENSP00000380967
ENST00000397868
ENST00000397866 ENSP00000380964
ENST00000397865 ENSP00000380963
ENST00000397863 ENSP00000380961
ENST00000397860 ENSP00000380958
ENST00000447114 ENSP00000405882
ENST00000490319
ENST00000473302 ENSP00000432988
ENST00000483025 ENSP00000442393
ENST00000493623 ENSP00000436951
ENST00000484548
ENST00000467108
ENST00000459948 ENSP00000435322
ENST00000482445
ENST00000487778
ENST00000490754
ENST00000495162
ENST00000497479
ENST00000498683 ENSP00000437063
ENST00000493247
ENST00000527041 ENSP00000435243
ENST00000528160 ENSP00000436830
ENST00000527975 ENSP00000431267
ENST00000531144 ENSP00000431335
ENST00000533278 ENSP00000434011
ENST00000526111 ENSP00000435641
ENST00000583798 ENSP00000463164
ENST00000580473
ENST00000578715
ENST00000585216
ENST00000577755 ENSP00000462780
ENST00000581179
ENST00000582282
ENST00000583266
ENST00000583474 ENSP00000462758
ENST00000578193 ENSP00000463403
ENST00000583118
ENST00000585201 ENSP00000462734
ENST00000579129 ENSP00000463780
ENST00000580402 ENSP00000462223
ENST00000578873 ENSP00000463137
ENST00000581878 ENSP00000462374
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0019911 structural constituent of myelin sheath
Biological Process
GO:0006955 immune response
GO:0007268 synaptic transmission
GO:0007417 central nervous system development
GO:0007568 aging
GO:0008366 axon ensheathment
GO:0009636 response to toxic substance
GO:0021762 substantia nigra development
GO:0032570 response to progesterone
GO:0034612 response to tumor necrosis factor
GO:0042552 myelination
GO:0046689 response to mercury ion
GO:0050771 negative regulation of axonogenesis
GO:0061024 membrane organization
GO:0070542 response to fatty acid
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0033269 internode region of axon
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0043218 compact myelin
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.551713 Hs.607968
RefSeq NM_001025081 NM_001025090 NM_001025092 NM_001025100 NM_001025101 NM_002385 XM_005266699
HUGO
OMIM
CCDS CCDS12011 CCDS32847 CCDS42448 CCDS42449 CCDS42450
HPRD 01158
IMGT
EMBL
GenPept
RNA Seq Atlas