InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDK3

Summary

InnateDB Gene

IDBG-52915.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDK3

Gene Name

pyruvate dehydrogenase kinase, isozyme 3

Synonyms

CMTX6; GS1-358P8.4

Species

Homo sapiens

Ensembl Gene

ENSG00000067992

Encoded Proteins

IDBP-52917

pyruvate dehydrogenase kinase, isozyme 3

IDBP-365761

pyruvate dehydrogenase kinase, isozyme 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:24465221-24539837

Strand

Forward strand

Band

p22.11

Transcripts

ENST00000379162	ENSP00000368460
ENST00000441463	ENSP00000387536
ENST00000493226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006090	pyruvate metabolic process
GO:0008219	cell death
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0018105	peptidyl-serine phosphorylation
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0071333	cellular response to glucose stimulus
GO:0071398	cellular response to fatty acid
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035232

View Gene Order

ENSBTAG00000017832

Not yet available

Pathways

NETPATH

REACTOME

REACT_12528

Regulation of pyruvate dehydrogenase (PDH) complex pathway

REACT_2071

Pyruvate metabolism pathway

REACT_1046

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.666585

RefSeq

NM_001142386 NM_005391

HUGO

OMIM

CCDS

CCDS14212 CCDS48088

HPRD

03956

IMGT

EMBL

GenPept

RNA Seq Atlas