Version 5.4
Homo sapiens Gene: CUL4A
Summary
InnateDB Gene IDBG-52956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUL4A
Gene Name cullin 4A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139842
Encoded Proteins
IDBP-52958
cullin 4A
IDBP-52960
cullin 4A
IDBP-52962
cullin 4A
IDBP-374302
cullin 4A
IDBP-808252
cullin 4A
IDBP-808231
cullin 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113208193-113267108
Strand Forward strand
Band q34
Transcripts
ENST00000375441 ENSP00000364590
ENST00000326335 ENSP00000322132
ENST00000375440 ENSP00000364589
ENST00000451881 ENSP00000389118
ENST00000488558 ENSP00000480367
ENST00000474116
ENST00000494985
ENST00000463426
ENST00000498562
ENST00000470067
ENST00000472083
ENST00000617546 ENSP00000481782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 327 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 327 [view]
Protein-Protein 327 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007050 cell cycle arrest
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0030097 hemopoiesis
GO:0030853 negative regulation of granulocyte differentiation
GO:0035019 somatic stem cell maintenance
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051246 regulation of protein metabolic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000001 regulation of DNA damage checkpoint
GO:2000819 regulation of nucleotide-excision repair
Cellular Component
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031446
View Gene Order
ENSBTAG00000020093
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa03420
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001008895 NM_001278513 NM_001278514 NM_003589
HUGO
OMIM
CCDS CCDS41908 CCDS73604 CCDS9533
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca