Version 5.4
Homo sapiens Gene: MPP2
Summary
InnateDB Gene IDBG-53094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPP2
Gene Name membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Synonyms DLG2
Species Homo sapiens
Ensembl Gene ENSG00000108852
Encoded Proteins
IDBP-53098
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-53100
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-475075
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-485456
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-483594
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-483922
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-476569
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-811306
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-476383
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-475455
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-478554
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-483925
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-481810
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-811308
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-474863
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-480911
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-586248
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-811309
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
IDBP-811310
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:43875357-43909711
Strand Reverse strand
Band q21.31
Transcripts
ENST00000269095 ENSP00000269095
ENST00000377184 ENSP00000366389
ENST00000461854 ENSP00000428286
ENST00000520305 ENSP00000428136
ENST00000523501 ENSP00000430540
ENST00000518766 ENSP00000428182
ENST00000523220 ENSP00000428468
ENST00000473246 ENSP00000479767
ENST00000520319
ENST00000520406 ENSP00000428354
ENST00000523762 ENSP00000428218
ENST00000523934 ENSP00000430797
ENST00000520241 ENSP00000428938
ENST00000521178 ENSP00000430443
ENST00000524294 ENSP00000483278
ENST00000522172 ENSP00000430349
ENST00000518478 ENSP00000429364
ENST00000536246 ENSP00000438012
ENST00000612133 ENSP00000478528
ENST00000622681 ENSP00000480071
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004385 guanylate kinase activity
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0007165 signal transduction
GO:0046939 nucleotide phosphorylation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017314
View Gene Order
ENSBTAG00000001279
Not yet available
Cross-References
SwissProt Q14168
TrEMBL B4DZ84
UniProt Splice Variant
Entrez Gene 4355
UniGene Hs.514208
RefSeq NM_001278375 NM_001278370 NM_001278371 NM_001278372 NM_001278373 NM_001278374 NM_001278376 NM_001278381 NM_005374 XM_006721912 XM_006721913 XM_006721914
HUGO HGNC:7220
OMIM 600723
CCDS CCDS62207 CCDS11471 CCDS62206 CCDS62208 CCDS62209 CCDS62210
HPRD 02837
IMGT
EMBL AC007993 AK223560 AK294564 AK295858 AK299286 AK302793 AL136554 BC030287 CR936598 X82895
GenPept AAH30287 BAD97280 BAG57760 BAG61302 BAG63996 BAH12204 CAA58067 CAB66489 CAI56746
RNA Seq Atlas 4355

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca