Version 5.4
Homo sapiens Gene: DRAM1
Summary
InnateDB Gene IDBG-53472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRAM1
Gene Name DNA-damage regulated autophagy modulator 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136048
Encoded Proteins
IDBP-53474
DNA-damage regulated autophagy modulator 1
IDBP-585851
DNA-damage regulated autophagy modulator 1
IDBP-599379
DNA-damage regulated autophagy modulator 1
IDBP-587484
DNA-damage regulated autophagy modulator 1
IDBP-598278
DNA-damage regulated autophagy modulator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:101877351-102012130
Strand Forward strand
Band q23.2
Transcripts
ENST00000258534 ENSP00000258534
ENST00000544152 ENSP00000445827
ENST00000551403 ENSP00000448075
ENST00000549365 ENSP00000447171
ENST00000549066 ENSP00000447906
ENST00000546729
ENST00000614926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006914 autophagy
GO:0030262 apoptotic nuclear changes
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020057
View Gene Order
ENSBTAG00000017287
Not yet available
Cross-References
SwissProt Q8N682
TrEMBL A0A024RBF9 B7Z4T0
UniProt Splice Variant
Entrez Gene 55332
UniGene Hs.525634
RefSeq NM_018370
HUGO HGNC:25645
OMIM 610776
CCDS CCDS41823
HPRD
IMGT
EMBL AC063950 AC079907 AC084398 AK002121 AK297785 BC013773 BC018435 CH471054
GenPept AAH13773 AAH18435 BAA92091 BAH12666 EAW97685 EAW97686
RNA Seq Atlas 55332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca