Homo sapiens Gene: OTX1
Summary
InnateDB Gene IDBG-53614.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTX1
Gene Name orthodenticle homeobox 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115507
Encoded Proteins
orthodenticle homeobox 1
orthodenticle homeobox 1
orthodenticle homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternate splicing results in two transcript variants that encoded the same protein.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:63050057-63057836
Strand Forward strand
Band p15
Transcripts
ENST00000282549 ENSP00000282549
ENST00000366671 ENSP00000355631
ENST00000405984 ENSP00000385782
ENST00000484066
ENST00000477348
ENST00000476383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0009952 anterior/posterior pattern specification
GO:0022037 metencephalon development
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0042472 inner ear morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048852 diencephalon morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445340 Hs.734360
RefSeq NM_001199770 NM_014562 XM_006712025
HUGO
OMIM
CCDS CCDS1873
HPRD 08964
IMGT
EMBL
GenPept
RNA Seq Atlas