Version 5.4
Homo sapiens Gene: OTX1
Summary
InnateDB Gene IDBG-53614.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTX1
Gene Name orthodenticle homeobox 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115507
Encoded Proteins
IDBP-53616
orthodenticle homeobox 1
IDBP-107351
orthodenticle homeobox 1
IDBP-293056
orthodenticle homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternate splicing results in two transcript variants that encoded the same protein.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:63050057-63057836
Strand Forward strand
Band p15
Transcripts
ENST00000282549 ENSP00000282549
ENST00000366671 ENSP00000355631
ENST00000405984 ENSP00000385782
ENST00000484066
ENST00000477348
ENST00000476383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0009952 anterior/posterior pattern specification
GO:0022037 metencephalon development
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0042472 inner ear morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048852 diencephalon morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005917
View Gene Order
ENSBTAG00000006760
Not yet available
Cross-References
SwissProt P32242
TrEMBL B4DM62 Q9P2R2
UniProt Splice Variant
Entrez Gene 5013
UniGene Hs.445340 Hs.734360
RefSeq NM_014562 NM_001199770 XM_006712025
HUGO HGNC:8521
OMIM 600036
CCDS CCDS1873
HPRD 08964
IMGT
EMBL AB037501 AC009501 AK095680 AK297308 BC007621 CH471053
GenPept AAH07621 AAY24357 BAA90421 BAG53106 BAG59774 EAW99967
RNA Seq Atlas 5013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca