InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS14

Summary

InnateDB Gene

IDBG-53709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS14

Gene Name

ribosomal protein S14

Synonyms

EMTB; S14

Species

Homo sapiens

Ensembl Gene

ENSG00000164587

Encoded Proteins

IDBP-53711

ribosomal protein S14

IDBP-295274

ribosomal protein S14

IDBP-295271

ribosomal protein S14

IDBP-480824

ribosomal protein S14

IDBP-476725

ribosomal protein S14

IDBP-476450

ribosomal protein S14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:150443190-150449756

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000312037	ENSP00000311028
ENST00000401695	ENSP00000385958
ENST00000407193	ENSP00000385425
ENST00000521466	ENSP00000428509
ENST00000518139	ENSP00000429856
ENST00000519690
ENST00000519855	ENSP00000428536

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	135 [view]
Protein-Protein	134 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006417	regulation of translation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0030218	erythrocyte differentiation
GO:0030490	maturation of SSU-rRNA
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome