Homo sapiens Gene: GK
Summary
InnateDB Gene IDBG-53826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GK
Gene Name glycerol kinase
Synonyms GK1; GKD;
Species Homo sapiens
Ensembl Gene ENSG00000198814
Encoded Proteins
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
glycerol kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:30653359-30731456
Strand Forward strand
Band p21.2
Transcripts
ENST00000378946 ENSP00000368229
ENST00000378945 ENSP00000368228
ENST00000378943 ENSP00000368226
ENST00000378941 ENSP00000368224
ENST00000378938 ENSP00000368221
ENST00000427190 ENSP00000401720
ENST00000425166 ENSP00000404682
ENST00000481024 ENSP00000418873
ENST00000479048 ENSP00000420676
ENST00000487652 ENSP00000419332
ENST00000471362 ENSP00000417942
ENST00000488296 ENSP00000419771
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004370 glycerol kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006071 glycerol metabolic process
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006641 triglyceride metabolic process
GO:0016310 phosphorylation
GO:0019432 triglyceride biosynthetic process
GO:0019563 glycerol catabolic process
GO:0042593 glucose homeostasis
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046167 glycerol-3-phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Triglyceride Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
KEGG
Glycerolipid metabolism pathway
PPAR signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1466 Hs.602658 Hs.617561
RefSeq NM_000167 NM_001128127 NM_001205019 NM_203391 XM_005274488 XM_006724485 XM_006724486
HUGO
OMIM
CCDS CCDS14225 CCDS35224 CCDS48090 CCDS75963
HPRD 08363
IMGT
EMBL
GenPept
RNA Seq Atlas