InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GK

Summary

InnateDB Gene

IDBG-53826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

glycerol kinase

Synonyms

GK1; GKD

Species

Homo sapiens

Ensembl Gene

ENSG00000198814

Encoded Proteins

IDBP-53830

glycerol kinase

IDBP-53832

glycerol kinase

IDBP-53834

glycerol kinase

IDBP-53836

glycerol kinase

IDBP-53838

glycerol kinase

IDBP-366347

glycerol kinase

IDBP-366351

glycerol kinase

IDBP-484710

glycerol kinase

IDBP-484390

glycerol kinase

IDBP-478092

glycerol kinase

IDBP-481793

glycerol kinase

IDBP-476291

glycerol kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:30653359-30731456

Strand

Forward strand

Band

p21.2

Transcripts

ENST00000378946	ENSP00000368229
ENST00000378945	ENSP00000368228
ENST00000378943	ENSP00000368226
ENST00000378941	ENSP00000368224
ENST00000378938	ENSP00000368221
ENST00000427190	ENSP00000401720
ENST00000425166	ENSP00000404682
ENST00000481024	ENSP00000418873
ENST00000479048	ENSP00000420676
ENST00000487652	ENSP00000419332
ENST00000471362	ENSP00000417942
ENST00000488296	ENSP00000419771

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004370	glycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006071	glycerol metabolic process
GO:0006072	glycerol-3-phosphate metabolic process
GO:0006641	triglyceride metabolic process
GO:0016310	phosphorylation
GO:0019432	triglyceride biosynthetic process
GO:0019563	glycerol catabolic process
GO:0042593	glucose homeostasis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046167	glycerol-3-phosphate biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000025059

View Gene Order

Pathways

NETPATH

REACTOME

REACT_1190

Triglyceride Biosynthesis pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa03320

PPAR signaling pathway pathway

hsa00561

Glycerolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.1466 Hs.602658 Hs.617561

RefSeq

NM_000167 NM_001128127 NM_001205019 NM_203391 XM_005274488 XM_006724485 XM_006724486

HUGO

OMIM

CCDS

CCDS14225 CCDS35224 CCDS48090 CCDS75963

HPRD

08363

IMGT

EMBL

GenPept

RNA Seq Atlas