InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PELI1

Summary

InnateDB Gene

IDBG-53855.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PELI1

Gene Name

pellino E3 ubiquitin protein ligase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000197329

Encoded Proteins

IDBP-53857

pellino homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19734906

PELI1 is a ubiquitin ligase that facilitates TRIF-dependent Toll-like receptor signalling and pro-inflammatory cytokine production.

PMID 17997719

PELI1 (pellino) isoforms are E3 ubiquitin ligases that mediate the IL-1-stimulated formation of K63-pUb-IRAK1 in cells, contributing to the activation of IKBKB and NF-kappaB, as well as other signalling pathways dependent on IRAK1 and IRAK4.

PMID 20171181

Discrete regions of PELI1 are bound by SMAD6 and SMAD7 via their MH2 domains to mediate TGF-beta1-induced negative regulation of IL-1R/TLR signalling.

PMID 21120624

PELI1 is an adaptor protein involved in IL1R/TLR signaling. PELI1 is sumoylated by SUMO1at 5 lysine residues, and binds to the SUMO-conjugating enzyme UBE2I.

PMID 26082489

Endotoxin tolerance re-programs TLR4 signalling via suppression of PELI1, a positive regulator of MyD88- and TIR domain-containing adapter inducing IFN-β (TRIF)-dependent signalling that promotes K63-linked polyubiquitination of IRAK1, TBK1, and TAK1.

InnateDB Annotation from Orthologs

Summary

PMID 26131354

[Mus musculus] Peli1 is an innate immune regulator in the central nervous system that modulates the threshold of Type I interferon responses against viral infections.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:64092652-64144454

Strand

Reverse strand

Band

p14

Transcripts

ENST00000358912	ENSP00000351789
ENST00000466177
ENST00000494203
ENST00000468869

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0001819	positive regulation of cytokine production
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0008063	Toll signaling pathway
GO:0030890	positive regulation of B cell proliferation
GO:0031398	positive regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032496	response to lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042130	negative regulation of T cell proliferation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043331	response to dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0050868	negative regulation of T cell activation
GO:0050871	positive regulation of B cell activation
GO:0070936	protein K48-linked ubiquitination