Homo sapiens Gene: SLC22A12
Summary
InnateDB Gene IDBG-54113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A12
Gene Name solute carrier family 22 (organic anion/urate transporter), member 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197891
Encoded Proteins
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64590641-64602353
Strand Forward strand
Band q13.1
Transcripts
ENST00000377574 ENSP00000366797
ENST00000336464 ENSP00000336836
ENST00000377572 ENSP00000366795
ENST00000377567 ENSP00000366790
ENST00000473690 ENSP00000438437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015143 urate transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0030165 PDZ domain binding
Biological Process
GO:0015747 urate transport
GO:0015849 organic acid transport
GO:0019725 cellular homeostasis
GO:0042493 response to drug
GO:0046415 urate metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Organic anion transport pathway
Organic cation/anion/zwitterion transport pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96S37
TrEMBL
UniProt Splice Variant
Entrez Gene 116085
UniGene Hs.174424 Hs.690995 Hs.742477
RefSeq NM_001276326 NM_001276327 NM_144585 NM_153378
HUGO HGNC:17989
OMIM 607096
CCDS CCDS60836 CCDS60835 CCDS8075
HPRD 06160
IMGT
EMBL AB050269 AB071863 AC044790 AK315061 AP001092 AY358183 BC053348 CH471076 DQ514593 DQ514594 DQ514595 DQ514596
GenPept AAH53348 AAK68156 AAQ88550 ABF74570 ABF74571 ABF74572 ABF74573 BAB68364 BAB96750 EAW74273 EAW74274
RNA Seq Atlas 116085