InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: JAG1

Summary

InnateDB Gene

IDBG-54207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JAG1

Gene Name

jagged 1

Synonyms

AGS; AHD; AWS; CD339; HJ1; JAGL1

Species

Homo sapiens

Ensembl Gene

ENSG00000101384

Encoded Proteins

IDBP-54209

jagged 1

IDBP-808857

jagged 1

IDBP-808859

jagged 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:10637684-10674107

Strand

Reverse strand

Band

p12.2

Transcripts

ENST00000254958	ENSP00000254958
ENST00000423891
ENST00000488480
ENST00000617357
ENST00000612857
ENST00000613518	ENSP00000481034
ENST00000622545	ENSP00000484139
ENST00000620743
ENST00000617965

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	17 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005198	structural molecule activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001525	angiogenesis
GO:0001709	cell fate determination
GO:0001974	blood vessel remodeling
GO:0002011	morphogenesis of an epithelial sheet
GO:0002456	T cell mediated immunity
GO:0003184	pulmonary valve morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0009887	organ morphogenesis
GO:0030097	hemopoiesis
GO:0030216	keratinocyte differentiation
GO:0030334	regulation of cell migration
GO:0032495	response to muramyl dipeptide
GO:0035909	aorta morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042491	auditory receptor cell differentiation
GO:0043010	camera-type eye development
GO:0045445	myoblast differentiation
GO:0045446	endothelial cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045639	positive regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development
GO:0060411	cardiac septum morphogenesis
GO:0061073	ciliary body morphogenesis
GO:0061156	pulmonary artery morphogenesis
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061314	Notch signaling involved in heart development
GO:0061444	endocardial cushion cell development
GO:0072017	distal tubule development
GO:0072070	loop of Henle development
GO:0097150	neuronal stem cell maintenance
GO:2000737	negative regulation of stem cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell