Version 5.4
Homo sapiens Gene: SPRED2
Summary
InnateDB Gene IDBG-54314.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRED2
Gene Name sprouty-related, EVH1 domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198369
Encoded Proteins
IDBP-54316
sprouty-related, EVH1 domain containing 2
IDBP-377950
sprouty-related, EVH1 domain containing 2
IDBP-377953
sprouty-related, EVH1 domain containing 2
IDBP-377957
sprouty-related, EVH1 domain containing 2
IDBP-377959
sprouty-related, EVH1 domain containing 2
IDBP-377962
sprouty-related, EVH1 domain containing 2
IDBP-377964
sprouty-related, EVH1 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:65310851-65432637
Strand Reverse strand
Band p14
Transcripts
ENST00000356388 ENSP00000348753
ENST00000443619 ENSP00000393697
ENST00000452315 ENSP00000390595
ENST00000421087 ENSP00000407627
ENST00000426832 ENSP00000414551
ENST00000440972 ENSP00000406481
ENST00000427238 ENSP00000393148
ENST00000474228
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005173 stem cell factor receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311 regulation of protein deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045671
View Gene Order
ENSBTAG00000019456
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL H7C2T4
UniProt Splice Variant
Entrez Gene 200734
UniGene Hs.59332
RefSeq NM_001128210 NM_181784 XM_005264201 XM_006711966
HUGO HGNC:17722
OMIM 609292
CCDS CCDS33211 CCDS46308
HPRD 18100
IMGT
EMBL AC012370 AC097503
GenPept
RNA Seq Atlas 200734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca