InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDKN2B

Summary

InnateDB Gene

IDBG-54658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN2B

Gene Name

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Synonyms

CDK4I; INK4B; MTS2; P15; p15INK4b; TP15

Species

Homo sapiens

Ensembl Gene

ENSG00000147883

Encoded Proteins

IDBP-54660

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

IDBP-54662

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:22002903-22009363

Strand

Reverse strand

Band

p21.3

Transcripts

ENST00000276925	ENSP00000276925
ENST00000380142	ENSP00000369487
ENST00000579591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	17 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007093	mitotic cell cycle checkpoint
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007568	aging
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0014070	response to organic cyclic compound
GO:0030219	megakaryocyte differentiation
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030858	positive regulation of epithelial cell differentiation
GO:0031668	cellular response to extracellular stimulus
GO:0031670	cellular response to nutrient
GO:0034097	response to cytokine
GO:0042326	negative regulation of phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle