Homo sapiens Gene: CHMP1B
Summary
InnateDB Gene IDBG-547095.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP1B
Gene Name charged multivesicular body protein 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000255112
Encoded Proteins
charged multivesicular body protein 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:11851396-11854449
Strand Forward strand
Band p11.21
Transcripts
ENST00000526991 ENSP00000432279
ENST00000588284
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000910 cytokinesis
GO:0007034 vacuolar transport
GO:0015031 protein transport
GO:0045184 establishment of protein localization
Cellular Component
GO:0005829 cytosol
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q7LBR1
TrEMBL B2RA72
UniProt Splice Variant
Entrez Gene 57132
UniGene Hs.656244
RefSeq NM_020412
HUGO HGNC:24287
OMIM 606486
CCDS CCDS54180
HPRD 12106
IMGT
EMBL AF281064 AF306520 AK314068 BC012733 BC065933
GenPept AAG01449 AAH12733 AAH65933 AAL48200 BAG36769
RNA Seq Atlas 57132