Version 5.4
Homo sapiens Gene: EEF1G
Summary
InnateDB Gene IDBG-547100.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF1G
Gene Name eukaryotic translation elongation factor 1 gamma
Synonyms EF1G; GIG35
Species Homo sapiens
Ensembl Gene ENSG00000254772
Encoded Proteins
IDBP-51082
eukaryotic translation elongation factor 1 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62559601-62574086
Strand Reverse strand
Band q12.3
Transcripts
ENST00000329251 ENSP00000331901
ENST00000525340
ENST00000524420
ENST00000532986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 160 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 160 [view]
Protein-Protein 159 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071644
View Gene Order
ENSBTAG00000011843
Not yet available
Pathways
NETPATH
REACTOME
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P26641
TrEMBL Q2F840 Q53YD7
UniProt Splice Variant
Entrez Gene 1937
UniGene
RefSeq NM_001404
HUGO HGNC:3213
OMIM 130593
CCDS CCDS44626
HPRD
IMGT
EMBL AF119850 AY542307 BC000384 BC006509 BC006520 BC007949 BC009865 BC013918 BC015813 BC021974 BC028179 BC031012 BC067738 BT006677 CH471076 CR407625 DQ185034 M55409 X63526 Z11531
GenPept AAC18414 AAF69604 AAH00384 AAH06509 AAH06520 AAH07949 AAH09865 AAH13918 AAH15813 AAH21974 AAH28179 AAH31012 AAH67738 AAP35323 AAT08176 ABD14418 CAA45089 CAA77630 CAG28553 EAW74025
RNA Seq Atlas 100500804 1937

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca