Version 5.4
| Homo sapiens Gene: KLC1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-547129.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | KLC1 | ||||||||
| Gene Name | Kinesin light chain 1 | ||||||||
| Synonyms | KLC; KNS2; KNS2A | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000256500 | ||||||||
| Encoded Proteins |
UPF0671 protein C14orf153
UPF0671 protein C14orf153
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008] Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 14:103562962-103685924 | ||||||||
| Strand | Forward strand | ||||||||
| Band | q32.33 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
| No orthologs found for this gene | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | E7EVH7 G3V2P7 Q7Z5D5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 3831 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_032374 | ||||||||
| HUGO | |||||||||
| OMIM | 600025 | ||||||||
| CCDS | CCDS9983 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF527736 AL049840 AL139300 | ||||||||
| GenPept | AAP85635 | ||||||||
| RNA Seq Atlas | 3831 | ||||||||