Homo sapiens Gene: RNASE4
Summary
InnateDB Gene IDBG-547170.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE4
Gene Name ribonuclease 4 precursor
Synonyms RAB1; RNS4;
Species Homo sapiens
Ensembl Gene ENSG00000258818
Encoded Proteins
Ribonuclease 4
Ribonuclease 4
Ribonuclease 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3\' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5\' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:20684100-20701215
Strand Forward strand
Band q11.2
Transcripts
ENST00000397995 ENSP00000381081
ENST00000555835 ENSP00000452245
ENST00000555597 ENSP00000451624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004522 pancreatic ribonuclease activity
Biological Process
GO:0006379 mRNA cleavage
GO:0009267 cellular response to starvation
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.283749 Hs.730830
RefSeq NM_001282192 NM_001282193 NM_002937 NM_194431
HUGO
OMIM
CCDS CCDS9555
HPRD 03018
IMGT
EMBL
GenPept
RNA Seq Atlas