Homo sapiens Gene: TUBB3
Summary
InnateDB Gene IDBG-547240.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUBB3
Gene Name Tubulin beta-3 chain
Synonyms beta-4; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; TUBB4;
Species Homo sapiens
Ensembl Gene ENSG00000258947
Encoded Proteins
tubulin, beta 3 class III
Melanocyte-stimulating hormone receptor
Melanocyte-stimulating hormone receptor
Melanocyte-stimulating hormone receptor
Melanocyte-stimulating hormone receptor
Melanocyte-stimulating hormone receptor
Melanocyte-stimulating hormone receptor
Melanocyte-stimulating hormone receptor
tubulin, beta 3 class III
tubulin, beta 3 class III
tubulin, beta 3 class III
tubulin, beta 3 class III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89921392-89938761
Strand Forward strand
Band q24.3
Transcripts
ENST00000315491 ENSP00000320295
ENST00000553656 ENSP00000452001
ENST00000556536 ENSP00000451378
ENST00000554116
ENST00000554927
ENST00000557262 ENSP00000451985
ENST00000557490 ENSP00000451465
ENST00000554336 ENSP00000450822
ENST00000555609 ENSP00000451276
ENST00000553967 ENSP00000450765
ENST00000555810 ENSP00000450538
ENST00000554444 ENSP00000451617
ENST00000556565 ENSP00000452166
ENST00000555576 ENSP00000452554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 90 [view]
Protein-Protein 89 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042277 peptide binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006457 protein folding
GO:0007017 microtubule-based process
GO:0007067 mitotic nuclear division
GO:0007411 axon guidance
GO:0030182 neuron differentiation
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0051258 protein polymerization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Formation of tubulin folding intermediates by CCT/TriC pathway
Protein folding pathway
Post-chaperonin tubulin folding pathway pathway
MHC class II antigen presentation pathway
Transmembrane transport of small molecules pathway
Kinesins pathway
Developmental Biology pathway
Signaling by Hedgehog pathway
Recruitment of NuMA to mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Transport of connexons to the plasma membrane pathway
Axon guidance pathway
Signal Transduction pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
Gap junction trafficking pathway
Chaperonin-mediated protein folding pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Recycling pathway of L1 pathway
Orphan transporters pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Gap junction assembly pathway
M Phase pathway
Mitotic Anaphase pathway
Centrosome maturation pathway
G2/M Transition pathway
Translocation of GLUT4 to the plasma membrane pathway
L1CAM interactions pathway
Factors involved in megakaryocyte development and platelet production pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
Resolution of Sister Chromatid Cohesion pathway
Gap junction trafficking and regulation pathway
Hemostasis pathway
Membrane Trafficking pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Phagosome pathway
Gap junction pathway
Pathogenic Escherichia coli infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.511743
RefSeq NM_001197181 NM_006086
HUGO
OMIM
CCDS CCDS10988 CCDS56012
HPRD 04044
IMGT
EMBL
GenPept
RNA Seq Atlas