Version 5.4
Homo sapiens Gene: PDF
Summary
InnateDB Gene IDBG-547353.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDF
Gene Name peptide deformylase (mitochondrial)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000258429
Encoded Proteins
IDBP-39045
peptide deformylase (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69328621-69330595
Strand Reverse strand
Band q22.1
Transcripts
ENST00000288022 ENSP00000288022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0042586 peptide deformylase activity
Biological Process
GO:0006412 translation
GO:0008284 positive regulation of cell proliferation
GO:0018206 peptidyl-methionine modification
GO:0031365 N-terminal protein amino acid modification
Cellular Component
GO:0005739 mitochondrion
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9HBH1
TrEMBL A0A024R6Y3
UniProt Splice Variant
Entrez Gene 64146
UniGene
RefSeq NM_022341
HUGO HGNC:30012
OMIM
CCDS CCDS10875
HPRD
IMGT
EMBL AF239156 AF322879 BC019912 CH471092
GenPept AAG33968 AAH19912 AAK15624 EAW83265 EAW83268
RNA Seq Atlas 64146

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca