Version 5.4
Homo sapiens Gene: MXD1
Summary
InnateDB Gene IDBG-55075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MXD1
Gene Name MAX dimerization protein 1
Synonyms BHLHC58; MAD; MAD1
Species Homo sapiens
Ensembl Gene ENSG00000059728
Encoded Proteins
IDBP-55077
MAX dimerization protein 1
IDBP-295642
MAX dimerization protein 1
IDBP-378409
MAX dimerization protein 1
IDBP-586406
MAX dimerization protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:69897688-69942945
Strand Forward strand
Band p13.3
Transcripts
ENST00000264444 ENSP00000264444
ENST00000410000
ENST00000409442 ENSP00000386523
ENST00000435990 ENSP00000410672
ENST00000465446
ENST00000540449 ENSP00000443935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 27 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0003714 transcription corepressor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001156
View Gene Order
ENSBTAG00000001042
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.468908 Hs.606254 Hs.608251 Hs.622132 Hs.707656
RefSeq NM_001202513 NM_001202514 NM_002357
HUGO
OMIM
CCDS CCDS1896 CCDS56123
HPRD 02487
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca