Homo sapiens Gene: MRPL22
Summary
InnateDB Gene IDBG-55126.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL22
Gene Name mitochondrial ribosomal protein L22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000082515
Encoded Proteins
mitochondrial ribosomal protein L22
mitochondrial ribosomal protein L22
mitochondrial ribosomal protein L22
mitochondrial ribosomal protein L22
mitochondrial ribosomal protein L22
mitochondrial ribosomal protein L22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:154941070-154969411
Strand Forward strand
Band q33.2
Transcripts
ENST00000265229 ENSP00000265229
ENST00000439747 ENSP00000411177
ENST00000523037 ENSP00000431040
ENST00000522038 ENSP00000429039
ENST00000519059 ENSP00000430648
ENST00000520040
ENST00000518364
ENST00000614620 ENSP00000481879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.483924
RefSeq NM_001014990 NM_014180
HUGO
OMIM
CCDS CCDS4331 CCDS43391
HPRD 14748
IMGT
EMBL
GenPept
RNA Seq Atlas