Version 5.4
Homo sapiens Gene: TEK
Summary
InnateDB Gene IDBG-55143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TEK
Gene Name TEK tyrosine kinase, endothelial
Synonyms CD202B; TIE-2; TIE2; VMCM; VMCM1
Species Homo sapiens
Ensembl Gene ENSG00000120156
Encoded Proteins
IDBP-55149
TEK tyrosine kinase, endothelial
IDBP-294896
TEK tyrosine kinase, endothelial
IDBP-484136
TEK tyrosine kinase, endothelial
IDBP-477369
TEK tyrosine kinase, endothelial
IDBP-807632
TEK tyrosine kinase, endothelial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:27109141-27230175
Strand Forward strand
Band p21.2
Transcripts
ENST00000380036 ENSP00000369375
ENST00000406359 ENSP00000383977
ENST00000519097 ENSP00000430686
ENST00000519080 ENSP00000428337
ENST00000615002 ENSP00000480251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0002040 sprouting angiogenesis
GO:0006468 protein phosphorylation
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0010033 response to organic substance
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016337 single organismal cell-cell adhesion
GO:0016525 negative regulation of angiogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030097 hemopoiesis
GO:0030334 regulation of cell migration
GO:0031100 organ regeneration
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043434 response to peptide hormone
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0046777 protein autophosphorylation
GO:0048014 Tie signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050900 leukocyte migration
GO:0051259 protein oligomerization
GO:0051591 response to cAMP
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060216 definitive hemopoiesis
GO:0060347 heart trabecula formation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1902533 positive regulation of intracellular signal transduction
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0001725 stress fiber
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006386
View Gene Order
ENSBTAG00000020148
Not yet available
Pathways
NETPATH
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
shp2_pathway
SHP2 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.89640
RefSeq NM_000459 NM_001290077 NM_001290078 XM_005251561 XM_005251562 XM_005251563
HUGO
OMIM
CCDS CCDS6519 CCDS75825
HPRD 02571
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca