Homo sapiens Gene: XRCC1
Summary
InnateDB Gene IDBG-55268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRCC1
Gene Name X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms RCC;
Species Homo sapiens
Ensembl Gene ENSG00000073050
Encoded Proteins
X-ray repair complementing defective repair in Chinese hamster cells 1
X-ray repair complementing defective repair in Chinese hamster cells 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:43543040-43580473
Strand Reverse strand
Band q13.31
Transcripts
ENST00000262887 ENSP00000262887
ENST00000543982 ENSP00000443671
ENST00000597811 ENSP00000470391
ENST00000599693 ENSP00000472128
ENST00000598422
ENST00000594511
ENST00000594107 ENSP00000471159
ENST00000595789
ENST00000598165 ENSP00000470045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 64 [view]
Protein-Protein 64 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005515 protein binding
Biological Process
GO:0000012 single strand break repair
GO:0001666 response to hypoxia
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010033 response to organic substance
GO:0021766 hippocampus development
GO:0042493 response to drug
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Resolution of Abasic Sites (AP sites) pathway
Base Excision Repair pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
DNA Repair pathway
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
E2F transcription factor network
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.98493
RefSeq NM_006297
HUGO
OMIM
CCDS CCDS12624
HPRD 01909
IMGT
EMBL
GenPept
RNA Seq Atlas