Version 5.4
Homo sapiens Gene: SART3
Summary
InnateDB Gene IDBG-55333.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SART3
Gene Name squamous cell carcinoma antigen recognized by T cells 3
Synonyms DSAP1; P100; p110; p110(nrb); RP11-13G14; TIP110
Species Homo sapiens
Ensembl Gene ENSG00000075856
Encoded Proteins
IDBP-55335
squamous cell carcinoma antigen recognized by T cells 3
IDBP-382636
squamous cell carcinoma antigen recognized by T cells 3
IDBP-593574
squamous cell carcinoma antigen recognized by T cells 3
IDBP-583465
squamous cell carcinoma antigen recognized by T cells 3
IDBP-602598
squamous cell carcinoma antigen recognized by T cells 3
IDBP-596238
squamous cell carcinoma antigen recognized by T cells 3
IDBP-599284
squamous cell carcinoma antigen recognized by T cells 3
IDBP-591913
squamous cell carcinoma antigen recognized by T cells 3
IDBP-601861
squamous cell carcinoma antigen recognized by T cells 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:108522580-108561400
Strand Reverse strand
Band q23.3
Transcripts
ENST00000228284 ENSP00000228284
ENST00000431469 ENSP00000414453
ENST00000546728 ENSP00000449743
ENST00000547397 ENSP00000447875
ENST00000546815 ENSP00000449386
ENST00000548582
ENST00000547528 ENSP00000446577
ENST00000546808
ENST00000548077
ENST00000548119
ENST00000550322 ENSP00000447324
ENST00000551416
ENST00000550619 ENSP00000449602
ENST00000552221
ENST00000546611 ENSP00000448554
ENST00000619503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
Experimentally validated
Total 93 [view]
Protein-Protein 91 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006396 RNA processing
GO:0010468 regulation of gene expression
GO:0048872 homeostasis of number of cells
GO:0071425 hematopoietic stem cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018974
View Gene Order
ENSBTAG00000031846
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_014706
HUGO
OMIM
CCDS CCDS9117
HPRD 11532
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca