InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MEN1

Summary

InnateDB Gene

IDBG-55362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEN1

Gene Name

multiple endocrine neoplasia I

Synonyms

MEAI; SCG2

Species

Homo sapiens

Ensembl Gene

ENSG00000133895

Encoded Proteins

IDBP-55364

multiple endocrine neoplasia I

IDBP-55366

multiple endocrine neoplasia I

IDBP-55368

multiple endocrine neoplasia I

IDBP-55370

multiple endocrine neoplasia I

IDBP-55372

multiple endocrine neoplasia I

IDBP-55374

multiple endocrine neoplasia I

IDBP-55376

multiple endocrine neoplasia I

IDBP-241708

multiple endocrine neoplasia I

IDBP-241710

multiple endocrine neoplasia I

IDBP-377907

multiple endocrine neoplasia I

IDBP-377909

multiple endocrine neoplasia I

IDBP-377910

multiple endocrine neoplasia I

IDBP-377912

multiple endocrine neoplasia I

IDBP-377913

multiple endocrine neoplasia I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:64803510-64811294

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000315422	ENSP00000323747
ENST00000312049	ENSP00000308975
ENST00000377326	ENSP00000366543
ENST00000377321	ENSP00000366538
ENST00000377316	ENSP00000366533
ENST00000337652	ENSP00000337088
ENST00000377313	ENSP00000366530
ENST00000394376	ENSP00000377901
ENST00000394374	ENSP00000377899
ENST00000440873	ENSP00000413944
ENST00000450708	ENSP00000394933
ENST00000413626	ENSP00000411218
ENST00000429702	ENSP00000402752
ENST00000424912	ENSP00000388016
ENST00000478548
ENST00000487019

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	99 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0000403	Y-form DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0030674	protein binding, bridging
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0047485	protein N-terminus binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001503	ossification
GO:0001776	leukocyte homeostasis
GO:0001933	negative regulation of protein phosphorylation
GO:0002051	osteoblast fate commitment
GO:0002076	osteoblast development
GO:0006281	DNA repair
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0009411	response to UV
GO:0010332	response to gamma radiation
GO:0010467	gene expression
GO:0016571	histone methylation
GO:0030097	hemopoiesis
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031062	positive regulation of histone methylation
GO:0032092	positive regulation of protein binding
GO:0032925	regulation of activin receptor signaling pathway
GO:0034968	histone lysine methylation
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045597	positive regulation of cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046329	negative regulation of JNK cascade
GO:0046621	negative regulation of organ growth
GO:0048704	embryonic skeletal system morphogenesis
GO:0051781	positive regulation of cell division
GO:0051974	negative regulation of telomerase activity
GO:0060021	palate development
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0032154	cleavage furrow
GO:0035097	histone methyltransferase complex
GO:0043234	protein complex