Version 5.4
Homo sapiens Gene: KIAA1267
Summary
InnateDB Gene IDBG-55420.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIAA1267
Gene Name KAT8 regulatory NSL complex subunit 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120071
Encoded Proteins
IDBP-55422
KIAA1267
IDBP-380176
KIAA1267
IDBP-759779
IDBP-762542
IDBP-760856
IDBP-757856
IDBP-761115
IDBP-763256
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46029916-46225374
Strand Reverse strand
Band q21.31
Transcripts
ENST00000262419 ENSP00000262419
ENST00000432791 ENSP00000387393
ENST00000572904 ENSP00000461484
ENST00000573286
ENST00000576248
ENST00000576870
ENST00000572218
ENST00000574590 ENSP00000461812
ENST00000571698 ENSP00000459330
ENST00000575318 ENSP00000461299
ENST00000574655 ENSP00000459359
ENST00000574963
ENST00000577114
ENST00000572679
ENST00000576739 ENSP00000459627
ENST00000573682
ENST00000576137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0006325 chromatin organization
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018412
View Gene Order
ENSBTAG00000012564
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.618377 Hs.619321 Hs.630341 Hs.648744 Hs.690905 Hs.700846
RefSeq NM_001193465 NM_001193466 NM_015443 XM_005257232 XM_005257233 XM_005257234 XM_005257235 XM_005275644 XM_005275645 XM_006721823 XM_006721824 XM_006721825 XM_006721826 XM_006725263 XM_006725264
HUGO
OMIM
CCDS CCDS11503 CCDS74084
HPRD 11254
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca