Homo sapiens Gene: RBFOX2
Summary
InnateDB Gene IDBG-5580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBFOX2
Gene Name RNA binding protein, fox-1 homolog (C. elegans) 2
Synonyms dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2; HRNBP2; RBM9; RTA;
Species Homo sapiens
Ensembl Gene ENSG00000100320
Encoded Proteins
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
RNA binding protein, fox-1 homolog (C. elegans) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:35738736-36028425
Strand Reverse strand
Band q12.3
Transcripts
ENST00000262829 ENSP00000262829
ENST00000359369 ENSP00000352328
ENST00000397305 ENSP00000380472
ENST00000397303 ENSP00000380470
ENST00000405409 ENSP00000384944
ENST00000408983 ENSP00000386177
ENST00000438146 ENSP00000413035
ENST00000416721 ENSP00000405651
ENST00000449924 ENSP00000391670
ENST00000414461 ENSP00000407855
ENST00000463509
ENST00000495377 ENSP00000474464
ENST00000491982
ENST00000473487 ENSP00000475142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0016070 RNA metabolic process
GO:0021942 radial glia guided migration of Purkinje cell
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0043484 regulation of RNA splicing
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048813 dendrite morphogenesis
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23543
UniGene
RefSeq NM_001031695 NM_001082576 NM_001082577 NM_001082578 NM_001082579 NM_014309 XM_005261433
HUGO HGNC:9906
OMIM 612149
CCDS CCDS13921 CCDS43013 CCDS46699 CCDS46700 CCDS46701
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 23543