Version 5.4
Homo sapiens Gene: RBFOX2
Summary
InnateDB Gene IDBG-5580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBFOX2
Gene Name RNA binding protein, fox-1 homolog (C. elegans) 2
Synonyms dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2; HRNBP2; RBM9; RTA
Species Homo sapiens
Ensembl Gene ENSG00000100320
Encoded Proteins
IDBP-5582
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-5586
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-235643
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-235645
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-294149
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-294136
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-374372
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-374379
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-374380
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-374387
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-812107
RNA binding protein, fox-1 homolog (C. elegans) 2
IDBP-812114
RNA binding protein, fox-1 homolog (C. elegans) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:35738736-36028425
Strand Reverse strand
Band q12.3
Transcripts
ENST00000262829 ENSP00000262829
ENST00000359369 ENSP00000352328
ENST00000397305 ENSP00000380472
ENST00000397303 ENSP00000380470
ENST00000405409 ENSP00000384944
ENST00000408983 ENSP00000386177
ENST00000438146 ENSP00000413035
ENST00000416721 ENSP00000405651
ENST00000449924 ENSP00000391670
ENST00000414461 ENSP00000407855
ENST00000463509
ENST00000495377 ENSP00000474464
ENST00000491982
ENST00000473487 ENSP00000475142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0016070 RNA metabolic process
GO:0021942 radial glia guided migration of Purkinje cell
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0043484 regulation of RNA splicing
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048813 dendrite morphogenesis
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033565
View Gene Order
ENSBTAG00000020125
Not yet available
Cross-References
SwissProt O43251
TrEMBL
UniProt Splice Variant
Entrez Gene 23543
UniGene Hs.604232 Hs.606140 Hs.609317 Hs.611624 Hs.676737 Hs.678617 Hs.713722
RefSeq NM_014309 XM_005261433 NM_001031695 NM_001082576 NM_001082577 NM_001082578 NM_001082579
HUGO HGNC:9906
OMIM 612149
CCDS CCDS13921 CCDS43013 CCDS46699 CCDS46700 CCDS46701
HPRD 15231
IMGT
EMBL AF229058 AK055213 AK291460 AL009266 AL049748 AL079295 AM419009 AY072786 AY960684 BC013115 BC025281 CR456559 DQ778625
GenPept AAH13115 AAH25281 AAL67150 AAL71905 AAX84843 ABG77459 BAB70875 BAF84149 CAA15842 CAG30445 CAI19059 CAL91352 CAQ07599 CAQ07600
RNA Seq Atlas 23543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca