Version 5.4
| Homo sapiens Gene: EXOC2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-55886.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | EXOC2 | ||||||||||||||||||
| Gene Name | exocyst complex component 2 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000112685 | ||||||||||||||||||
| Encoded Proteins |
exocyst complex component 2
exocyst complex component 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:485133-693111 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p25.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Insulin processing pathway
Translocation of GLUT4 to the plasma membrane pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
Membrane Trafficking pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI |
Arf6 trafficking events
Insulin Pathway
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| Cross-References | |||||||||||||||||||
| SwissProt | Q96KP1 | ||||||||||||||||||
| TrEMBL | A0A024QZT2 G8JLK9 Q2MDF5 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 55770 | ||||||||||||||||||
| UniGene | Hs.484412 | ||||||||||||||||||
| RefSeq | NM_018303 XM_006715141 XM_006715142 | ||||||||||||||||||
| HUGO | HGNC:24968 | ||||||||||||||||||
| OMIM | 615329 | ||||||||||||||||||
| CCDS | CCDS34327 | ||||||||||||||||||
| HPRD | 11544 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AJ414403 AK001888 AK314628 AL031770 AL357054 AL512308 AL833213 BC016918 BC080542 CH471087 | ||||||||||||||||||
| GenPept | AAH16918 AAH80542 BAA91963 BAG37193 CAC92092 CAH70772 CAI19790 CAI46189 EAW55061 EAW55062 | ||||||||||||||||||
| RNA Seq Atlas | 55770 | ||||||||||||||||||